From the earliest oil pioneers to today’s business startups, entrepreneurs have paved the road to success for Oklahoma. Small businesses account for more than 80% of the business community in each of the state’s two largest cities. Higher education must take a leadership role in developing and sustaining a thriving entrepreneurial ecosystem for small business. Community colleges are uniquely designed to nourish an entrepreneurial ecosystem in light of their ability to quickly respond to business and community needs, design curriculum to meet industry demands, and generate meaningful advances in the community’s economic development. Budding entrepreneurs often look to the community college as the most flexible and accessible means to reach their goal of starting a new business. A college involved in cultivating and nurturing an entrepreneurial ecosystem must exhibit its own entrepreneurial spirit while creating an environment where discoveries are made, learning is emphasized, and lives are changed.