Why are many urban universities’ relationships with their surrounding communities fraught despite university efforts at community engagement? Relationships between the factors underlying university-driven neighborhood change remain largely unexplored. In this article, I take the University of Pennsylvania (Penn) as a case study and examine the relationship between campus security on the one hand and university-related redevelopment projects in Penn’s West Philadelphia neighborhood on the other. I ask what this relationship can reveal about how university-driven neighborhood change operates and why Penn’s relationship with its community is persistently tense. I organize my data into two case studies and argue that campus safety and redevelopment have long worked hand-in-hand to securitize campus by creating and reinforcing private zones of exclusivity. Not only have crime and resulting security measures played a key role in driving redevelopment projects, but recently, redevelopment itself has further begun to serve as a form of securitization.