Creighton University, a private Jesuit institution in the Midwest, included a Health Professions Partnership Initiative (HPPI) to increase the pool of qualified underrepresented minority applicants by identifying students early and encouraging their progress through elementary and middle school, high school, college, and professional schools. Activities available to the five hundred student participants included workshops on study skills and time management, summer research institutes, enrichment activities including classroom presentations by medical professionals, shadowing, ACT skill building, priority registration for science and math programs, college prep planning, regular informational and social meetings, mentor/mentee sessions, and academic counseling. Quantitative and qualitative research results reveal that the HPPI was a successful collaboration yielding satisfactory results with the resources available to encourage academic achievement, the exploration of health sciences as a career choice, and development of positive attitudes of participants toward themselves, peers, academic success, health careers, health and safety issues, and Creighton University.